Biological descriptionPotent, selective CCR2 antagonist (Ki = 180 nM). Inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).
Chemical nameN-[2-[[(3R)-1-[(4-Chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Teijin compound 1 hydrochloride (ab120823)
This product has been referenced in:
Hall SE et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol75:1325-36 (2009).
Read more (PubMed: 19297521) »
Moree WJ et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett18:1869-73 (2008).
Read more (PubMed: 18313297) »
Moree WJ et al. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett14:5413-6 (2004).
Read more (PubMed: 15454236) »