Overview

  • Product nameTeijin compound 1 hydrochloride
  • Description
    Potent, selective CCR2 antagonist
  • Biological descriptionPotent, selective CCR2 antagonist (Ki = 180 nM). Inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).
  • Purity> 99%

Properties

  • Chemical nameN-[2-[[(3R)-1-[(4-Chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide hydrochloride
  • Molecular weight476.32
  • Chemical structureChemical Structure
  • Molecular formulaC21H21ClF3N3O2.HCl
  • CAS Number1313730-14-1
  • Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]3CCN(Cc2ccc(Cl)cc2)C3
  • Source

    Synthetic

  • Research areas

    References for Teijin compound 1 hydrochloride (ab120823)

    This product has been referenced in:
    • Hall SE  et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol 75:1325-36 (2009). Read more (PubMed: 19297521) »
    • Moree WJ  et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett 18:1869-73 (2008). Read more (PubMed: 18313297) »
    • Moree WJ  et al. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett 14:5413-6 (2004). Read more (PubMed: 15454236) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"