The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 56 kDa.
Use at an assay dependent dilution.
FunctionPlays a critical role in endothelial cell capillary morphogenesis.
Tissue specificityDetected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.
Sequence similaritiesBelongs to the plexin family.
Cellular localizationCytoplasm; Secreted and Cell membrane. Cell junction > tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
ab118874, at 5 µg/ml, staining TEM7 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry. This was followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-TEM7 antibody (ab118874)
has not yet been referenced specifically in any publications.
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