Overview

  • Product nameAnti-TEM7 antibody
    See all TEM7 primary antibodies
  • Description
    Rabbit polyclonal to TEM7
  • Specificityab80754 recognises human Tumour endothelial marker 7 (TEM7), a 55.8 kDa protein belonging to the plexin family. TEM7 is strongly expressed in endothelial cells from colorectal cancer and from primary cancers of the lung, liver, brain, breast and pancreas. High expression of TEM7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. Studies have indicated the existence of least four isoforms of TEM7 which include membrane bound, secreted and intracellular forms. TEM7 is not detectable in endothelial cells from normal tissues.
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    16 amino acid synthetic peptide corresponding to an internal sequence of Human TEM7

  • Positive control
    • Liver

Properties

Applications

Our Abpromise guarantee covers the use of ab80754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 56 kDa (predicted molecular weight: 56 kDa).
IHC-P Use a concentration of 2.5 µg/ml. Do not perform antigen retrieval.

Target

  • FunctionPlays a critical role in endothelial cell capillary morphogenesis.
  • Tissue specificityDetected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.
  • Sequence similaritiesBelongs to the plexin family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationCytoplasm; Secreted and Cell membrane. Cell junction > tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686F0937 antibody
    • FLJ36270 antibody
    • FLJ45632 antibody
    • OTTHUMP00000164240 antibody
    • Plexin domain containing 1 antibody
    • Plexin domain containing protein 1 precursor antibody
    • Plexin domain-containing protein 1 antibody
    • Plxdc1 antibody
    • PXDC1_HUMAN antibody
    • TEM3 antibody
    • TEM7 antibody
    • Tumor endothelial marker 3 antibody
    • Tumor endothelial marker 7 antibody
    see all

Anti-TEM7 antibody images

  • Lane 1 : Anti-TEM7 antibody (ab80754) at 0.5 µg/ml
    Lane 2 : Anti-TEM7 antibody (ab80754) at 1 µg/ml

    Lane 1 : rat liver lysate.
    Lane 2 : rat liver lysate.


    Predicted band size : 56 kDa
    Observed band size : 56 kDa
  • ab80754 at 2.5 µg/ml staining TEM7 in mouse liver by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References for Anti-TEM7 antibody (ab80754)

ab80754 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"