• Product nameAnti-TEM8 antibody [200C1339]
    See all TEM8 primary antibodies
  • Description
    Mouse monoclonal [200C1339] to TEM8
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 481-497 of Human TEM8.

  • Positive control
    • Tested with TEM8 transfected cell lysate.



Our Abpromise guarantee covers the use of ab13798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 84 kDa.

A 70 kD band was seen when cell extracts were treated with a glycosidase cocktail. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

IHC-P 1/200 - 1/400. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionPlays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • Tissue specificityDetected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • Involvement in diseaseDefects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • Sequence similaritiesBelongs to the ATR family.
    Contains 1 VWFA domain.
  • DomainBinding to PA occurs through the VWA domain.
  • Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody [200C1339] images

  • Western blot detection of TEM8 in TEM8 transfected cell lysate using ab13798 at 1 µg/ml.
  • Formalin-fixed, paraffin-embedded human colon stained with ab13798 diluted 1:200, detection using peroxidase-conjugated secondary antibody and DAB chromogen.
  • Formalin-fixed, paraffin-embedded human colon stained with ab13798 diluted 1:200, detection using peroxidase-conjugated secondary and DAB chromogen.

References for Anti-TEM8 antibody [200C1339] (ab13798)

This product has been referenced in:
  • Sakai Y  et al. Bcl-2 mediated modulation of vascularization in prostate cancer xenografts. Prostate 69:459-70 (2009). WB ; Human . Read more (PubMed: 19107861) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab13798.
Please use the links above to contact us or submit feedback about this product.