Overview

  • Product nameAnti-TEM8 antibody
    See all TEM8 primary antibodies
  • Description
    Goat polyclonal to TEM8
  • SpecificityThis antibody is expected to recognise variant 1 only.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: RAPPPSRPPPRPSV, corresponding to C terminal amino acids 551-564 of Human TEM8.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab15724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 65 kDa.Can be blocked with Human TEM8 peptide (ab23274).

Target

  • FunctionPlays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • Tissue specificityDetected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • Involvement in diseaseDefects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • Sequence similaritiesBelongs to the ATR family.
    Contains 1 VWFA domain.
  • DomainBinding to PA occurs through the VWA domain.
  • Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody images



  • Predicted band size : 65 kDa


    Western blot with Goat polyclonal to TEM8 (ab15724) at 0.3ug/ml. Human PBMC lysate (RIPA buffer, 35 ug total protein per lane). Primary ab incubated for 1 hour and detected by chemiluminescence.

References for Anti-TEM8 antibody (ab15724)

ab15724 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"