• Product nameAnti-TEM8 antibody
    See all TEM8 primary antibodies
  • Description
    Rabbit polyclonal to TEM8
  • SpecificityThis antibody will recognize only the largest isoform of TEM8.
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 13 amino acids near the C-terminal of TEM8 (Human).

  • Positive control
    • K562 cell lysates.


Associated products


Our Abpromise guarantee covers the use of ab21269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 63 kDa.


  • FunctionPlays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
  • Tissue specificityDetected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
  • Involvement in diseaseDefects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
  • Sequence similaritiesBelongs to the ATR family.
    Contains 1 VWFA domain.
  • DomainBinding to PA occurs through the VWA domain.
  • Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
  • Information by UniProt
  • Database links
  • Alternative names
    • Anthrax toxin receptor 1 antibody
    • ANTR1_HUMAN antibody
    • Antxr1 antibody
    • ATR antibody
    • Tumor endothelial marker 8 antibody
    see all

Anti-TEM8 antibody images

  • Lane 1 : Anti-TEM8 antibody (ab21269) at 0.5 µg/ml
    Lane 2 : Anti-TEM8 antibody (ab21269) at 1 µg/ml
    Lane 3 : Anti-TEM8 antibody (ab21269) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate
    Lane 3 : K562 cell lysate

    Predicted band size : 63 kDa
  • ab21269 at 2µg/ml staining TEM8 in K562 cells by ICC/IF

References for Anti-TEM8 antibody (ab21269)

ab21269 has not yet been referenced specifically in any publications.

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To our knowledge, neither of these antibodies have been used in any references yet. All of the known references for our products can be found on the Specific References tab of the online datasheet. Please let me k...

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Thank you for contacting us.

The attached ICC/IF protocol was used to validate ab129004 but would also be suitable for use with ab21269. The recommended dilutions for these antibodies are 1:250 - 500. I hope this helps, please let me know if ...

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