Overview

  • Product nameAnti-TEM8 antibody
    See all TEM8 primary antibodies
  • Description
    Rabbit polyclonal to TEM8
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    This polyclonal antibody was raised by immunizing rabbit with human TEM8 synthetic peptide, located near its N-terminal domain.

Properties

Applications

Our Abpromise guarantee covers the use of ab34268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/5000.
    WB: 1/5000 for analysis of recombinant protein, 1/400 for analysis of tissue extracts or cell lysates. Predicted molecular weight: 63 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
    • Tissue specificityDetected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
    • Involvement in diseaseDefects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma.
    • Sequence similaritiesBelongs to the ATR family.
      Contains 1 VWFA domain.
    • DomainBinding to PA occurs through the VWA domain.
    • Cellular localizationCell membrane. Cell projection > lamellipodium membrane. Cell projection > filopodium membrane. At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
    • Information by UniProt
    • Database links
    • Alternative names
      • Anthrax toxin receptor 1 antibody
      • ANTR1_HUMAN antibody
      • Antxr1 antibody
      • ATR antibody
      • Tumor endothelial marker 8 antibody
      see all

    References for Anti-TEM8 antibody (ab34268)

    ab34268 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab34268.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"