FunctionExtracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Sequence similaritiesBelongs to the tenascin family. Contains 15 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 15 fibronectin type-III domains.
Cellular localizationSecreted > extracellular space > extracellular matrix.