Overview

  • Product nameTertiapin Q
  • Description
    Potent inward rectifier K+ channel blocker
  • Biological descriptionPotent blocker of inward rectifier K+ channels. Stable analog of the bee venom tertiapin. High affinity for ROMK1 and GIRK1/4 (Ki values are 1.3 and 13.3 nM, respectively). Displays >250-fold selectivity over many other Kir subtypes.
  • Purity> 95%
  • General notesSold under license granted by the University of Pennsylvania.

Properties

    References for Tertiapin Q (ab120432)

    This product has been referenced in:
    • Ramu Y  et al. Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Proc Natl Acad Sci U S A 105:10774-8 (2008). Read more (PubMed: 18669667) »
    • Kanjhan R  et al. Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. J Pharmacol Exp Ther 314:1353-61 (2005). Read more (PubMed: 15947038) »
    • Jin W  et al. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q. Biochemistry 38:14294-301 (1999). Read more (PubMed: 10572004) »

    See all 2 Publications for this product

    Product Wall

    Thank you for contacting Abcam.

    We currently run our HPLC at 25°C and we do not believe that this should cause issue with the compound. Although we do not have experience with preparing samples in phosphate buffer, as this seems to be the...

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    Thank you for your reply.

    I have forwarded it to our lab for them to comment and I will contact you again as soon I hear back from them.

    Thank you for contacting Abcam.

    I have been in contact with the lab about the issue you were having with ab120432, Tertiapin Q. Please see their response below:

    Following your question, Tertiapin Q has been re-submitted for quality ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"