Anti-TET1 antibody (ab121587)


  • Product nameAnti-TET1 antibody
    See all TET1 primary antibodies
  • Description
    Rabbit polyclonal to TET1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    internal sequence amino acids 435-578 of Human TET1.

  • Positive control
    • Human skeletal muscle.



Our Abpromise guarantee covers the use of ab121587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.


  • FunctionDioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). Plays a role in embryonic stem (ES) cell maintenance and inner cell mass (ICM) cell specification, possibly by participating in DNA demethylation. Specifically binds 5mC, a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. 5mC is present in ES cells and is enriched in the brain, especially in Purkinje neurons. The clear function of hmC is still unclear but it could constitute an intermediate component in cytosine demethylation. A role of hmC in DNA demethylation is supported by TET1 function in ES cell maintenance, which is required to prevent NANOG hypermethylation and maintain NANOG expression in ES cells.
  • Tissue specificityExpressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain.
  • Involvement in diseaseNote=A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'.
  • Sequence similaritiesBelongs to the TET family.
    Contains 1 CXXC-type zinc finger.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA119F7.1 antibody
    • CXXC 6 antibody
    • CXXC finger 6 antibody
    • CXXC type zinc finger protein 6 antibody
    • CXXC zinc finger 6 antibody
    • CXXC-type zinc finger protein 6 antibody
    • CXXC6 antibody
    • KIAA1676 antibody
    • LCX antibody
    • Leukemia associated protein with a CXXC domain antibody
    • Leukemia-associated protein with a CXXC domain antibody
    • Methylcytosine dioxygenase TET1 antibody
    • Ten eleven translocation 1 antibody
    • Ten eleven translocation 1 gene protein antibody
    • Ten eleven translocation 1 gene protein homolog antibody
    • Ten-eleven translocation 1 gene protein antibody
    • Tet 1 antibody
    • Tet methylcytosine dioxygenase 1 antibody
    • Tet oncogene 1 antibody
    • TET1 antibody
    • TET1_HUMAN antibody
    see all

Anti-TET1 antibody images

  • ab121587, at a 1/300 dilution, staining TET1 in myocytes of paraffin-embedded Human skeletal muscle tissue by immunohistochemistry.
  • Immunohistochemical staining of Human skeletal muscle shows moderate cytoplasmic positivity in myocytes using ab121587

References for Anti-TET1 antibody (ab121587)

ab121587 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 25°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Wako target retrieval solution
Sample Marmoset (common) Tissue sections (adult testis)
Specification adult testis
Permeabilization No
Fixative Formaldehyde

煜欽 林

Verified customer

Submitted Dec 19 2013

Thank you very much for your reply.

Since we haven't tested ab121587 in Western blot, we aren't able to guarantee it and we don't offer a refund in this case. This seems risky, but with the AbTrial program you will be compensated (via the $39...

Read More

Expiration date: February 20, 2013
Value: $399

This code will give you $399 off your next order before the expiration date. To redeem this offer, please submit an Abreview for ab121587 in WB and include this code ...

Read More

Thank you vefor your call today and for your interest in ab121587.

Sinceab121587 has not been tested in Western blot, I can offer a discount off a future purchase if you buy ab121587 now, test it in Western blot, and submit feedback to us in...

Read More