Overview

  • Product name
  • Description
    Goat polyclonal to TFB2M
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide:

    KHCFGRRSATVIDH

    , corresponding to internal sequence amino acids 325-338 of Human TFB2M (NP_071761.1).

  • Positive control
    • Human Lung lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab116608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).

Target

  • Function
    S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
  • Tissue specificity
    Ubiquitously expressed.
  • Sequence similarities
    Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • N''-adenosyl(rRNA) dimethyltransferase 2 antibody
    • S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase 2 antibody
    • Dimethyladenosine transferase 2 antibody
    • dimethyladenosine transferase 2 mitochondrial antibody
    • FLJ22661 antibody
    • FLJ23182 antibody
    • h mtTFB antibody
    • h mtTFB2 antibody
    • h-mtTFB antibody
    • h-mtTFB2 antibody
    • HCV NS5A transactivated protein 5 antibody
    • HCV NS5A-transactivated protein 5 antibody
    • hepatitis C virus NS5A transactivated protein 5 antibody
    • Hepatitis C virus NS5A-transactivated protein 5 antibody
    • Hkp1 antibody
    • hTFB2M antibody
    • Mitochondrial 12S rRNA dimethylase 2 antibody
    • mitochondrial antibody
    • Mitochondrial dimethyladenosine transferase 2 antibody
    • Mitochondrial transcription factor B2 antibody
    • mtTFB antibody
    • mtTFB2 antibody
    • NS5ATP5 antibody
    • S-adenosylmethionine-6-N'' antibody
    • TFB2M antibody
    • TFB2M_HUMAN antibody
    • Transcription Factor B2 antibody
    • Transcription factor B2 mitochondrial antibody
    see all

Images

  • Anti-TFB2M antibody (ab116608) at 0.1 µg/ml + Human Lung lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 45 kDa

References

ab116608 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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