Overview

  • Product name
  • Description
    Goat polyclonal to TFEC
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: TLDHQIINPTLK, corresponding to N terminal amino acids 2-13 of Human TFEC.

  • Positive control
    • Human Testis lysate
  • General notes
    Principal Names - TFEC; transcription factor EC; TCFEC; TFECL Official Gene Symbol - TFEC GenBank Accession Number – NP_036384 LocusLink ID - 22797 (human) Gene Ontology terms - transcription co-repressor; transcription co-activator; transcription factor; nucleus

Properties

Applications

Our Abpromise guarantee covers the use of ab2653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/0.5 - 1/2. Detects a band of approximately 40-45 kDa (predicted molecular weight: 40 kDa).Can be blocked with Human TFEC peptide (ab22928).

Target

  • Function
    Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.
  • Tissue specificity
    Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.
  • Sequence similarities
    Belongs to the MiT/TFE family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bHLHe34 antibody
    • Class E basic helix-loop-helix protein 34 antibody
    • hTFEC-L antibody
    • TCFEC antibody
    • TFE-C antibody
    • Tfec antibody
    • TFEC protein antibody
    • TFEC_HUMAN antibody
    • TFECL antibody
    • Transcription factor EC antibody
    • Transcription factor EC-like antibody
    see all

Images



  • Predicted band size : 40 kDa


    ab2653 staining (1µg/ml) of Human Testis lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

References

ab2653 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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