• Product nameAnti-TFII I antibody
    See all TFII I primary antibodies
  • Description
    Mouse monoclonal to TFII I
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human, Recombinant Fragment
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 36-275 of Human TFII I



Our Abpromise guarantee covers the use of ab55200 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInteracts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.
    • Tissue specificityUbiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues.
    • Involvement in diseaseNote=GTF2I is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2I may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
    • Sequence similaritiesBelongs to the TFII-I family.
      Contains 6 GTF2I-like repeats.
    • Post-translational
      Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation.
    • Cellular localizationCytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • BAP 135 antibody
      • BAP-135 antibody
      • BAP135 antibody
      • Bruton tyrosine kinase associated protein 135 antibody
      • Bruton tyrosine kinase-associated protein 135 antibody
      • BTK associated protein 135 antibody
      • BTK associated protein 135kD antibody
      • BTK associated protein antibody
      • BTK-associated protein 135 antibody
      • BTKAP 1 antibody
      • BTKAP1 antibody
      • DIWS antibody
      • FLJ38776 antibody
      • FLJ56355 antibody
      • General transcription factor II i antibody
      • General transcription factor II-I antibody
      • General transcription factor IIi antibody
      • GTF 2I antibody
      • Gtf2i antibody
      • GTF2I_HUMAN antibody
      • GTFII I antibody
      • GTFII-I antibody
      • IB 291 antibody
      • IB291 antibody
      • SPIN antibody
      • SRF Phox 1 interacting protein antibody
      • SRF Phox1 interacting protein antibody
      • SRF-Phox1-interacting protein antibody
      • TFII-I antibody
      • Transcription factor II I antibody
      • WBS antibody
      • WBSCR 6 antibody
      • WBSCR6 antibody
      • Williams Beuren syndrome chromosome region 6 antibody
      • Williams Beuren syndrome chromosome region 6 protein antibody
      • Williams-Beuren syndrome chromosomal region 6 protein antibody
      see all

    Anti-TFII I antibody images

    • TFII I antibody (ab55200) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.
    • Western blot against tagged recombinant protein immunogen using ab55200 TFII I antibody at 1ug/ml. Predicted band size of immunogen is 52 kDa

    References for Anti-TFII I antibody (ab55200)

    ab55200 has not yet been referenced specifically in any publications.

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