Overview

  • Product name
  • Description
    Rabbit polyclonal to TFPT
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: RLHQVQRITR RLQQERRFLM RVLDSYGDDY RASQFTIVLE DEGSQGTDAP TPGNAENEPP EKETLS, corresponding to amino acids 102-167 of Human TFPT (UniProt ID: P0C1Z6).

  • Positive control
    • Human liver tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab122236 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Appears to promote apoptosis in a p53/TP53-independent manner.
    Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
  • Involvement in disease
    Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amida antibody
    • INO80 complex subunit F antibody
    • INO80F antibody
    • Protein FB1 antibody
    • TCF3 (E2A) fusion partner (in childhood Leukemia) antibody
    • TCF3 fusion partner antibody
    • TFPT antibody
    • TFPT_HUMAN antibody
    see all

Images

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus and nucleoli. Recommended concentration of ab122236 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122236, at a dilution of 1/250, staining TFPT in paraffin embedded Human liver tissue by Immunohistochemistry.

References

ab122236 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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