Overview

  • Product nameAnti-TGF beta 1 antibody [TGFB17]
    See all TGF beta 1 primary antibodies
  • Description
    Mouse monoclonal [TGFB17] to TGF beta 1
  • SpecificityMay crossreact with other members of the TGFB family.
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Prokaryotic recombinant protein corresponding to the full length mature transforming growth factor beta 1 molecule.

  • Positive control
    • Placenta.

Properties

Applications

Our Abpromise guarantee covers the use of ab49574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/40. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionMultifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
    • Tissue specificityHighly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.
    • Involvement in diseaseDefects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
    • Sequence similaritiesBelongs to the TGF-beta family.
    • Post-translational
      modifications
      Glycosylated.
      The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • CED antibody
      • DPD1 antibody
      • LAP antibody
      • Latency-associated peptide antibody
      • Prepro transforming growth factor beta 1 antibody
      • TGF beta 1 antibody
      • TGF beta antibody
      • TGF beta 1 protein antibody
      • TGF-beta 1 protein antibody
      • TGF-beta-1 antibody
      • TGF-beta-5 antibody
      • TGF-beta1 antibody
      • TGFB antibody
      • Tgfb-1 antibody
      • TGFB1 antibody
      • TGFB1_HUMAN antibody
      • TGFbeta antibody
      • TGFbeta1 antibody
      • Transforming Growth Factor b1 antibody
      • Transforming Growth Factor beta 1 antibody
      • Transforming growth factor beta 1a antibody
      • transforming growth factor beta-1 antibody
      • Transforming growth factor beta-1 precursor antibody
      • transforming growth factor, beta 1 antibody
      see all

    Anti-TGF beta 1 antibody [TGFB17] images

    • Human breast carcinoma: immunohistochemical staining for Transforming Growth Factor Beta 1 using 1/20 ab49574. Note cytoplasmic staining of tumor cells. Paraffin section.

    References for Anti-TGF beta 1 antibody [TGFB17] (ab49574)

    This product has been referenced in:
    • Tjin EP  et al. Immune-escape markers in relation to clinical outcome of advanced melanoma patients following immunotherapy. Cancer Immunol Res 2:538-46 (2014). Human . Read more (PubMed: 24894091) »
    • McCune BK  et al. Localization of transforming growth factor-beta isotypes in lesions of the human breast. Hum Pathol 23:13-20 (1992). Read more (PubMed: 1544664) »

    See all 2 Publications for this product

    Product Wall

    Thank you for contacting us. I sincerely apologize for the shortages and have arranged to send you replacements on order *******. The antibodies you received should still be fine to use, but you will receive the replacements tomorrow. Please let me kno...

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    Thank you very much for calling us. It was nice talking to you. As per our conversation we can confirm that all the antibodies are specifically tested in IHC-P with human tissue sections. Abcam guarantee that these antibodies will work in IHC-P. ...

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    Thank you for your enquiry. As there are numerous differences between antibodies ab49574 and ab1279, would it be possible for you to indicate to me specificially what applications you intend to use the antibodies for please? From your previous ...

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    Thank you for your enquiry. As far as we are aware, cross reactivity with pig tissue has not yet been tested for use with ab49574. All species cross-reactivity information is stated on Abcam product datasheets, and these are updated as soon as any ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"