The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionTGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
Involvement in diseaseA chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9. Loeys-Dietz syndrome 4 Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
Sequence similaritiesBelongs to the TGF-beta family.
Post-translational modificationsThe precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
ab75715, at a dilution of 1/50, staining TGF beta 2 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry. ab75715 was peroxidase conjugated to the secondary antibody, followed by DAB staining.
References for Anti-TGF beta 2 antibody (ab75715)
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