Anti-TGF beta 2 antibody (ab80059)
Key features and details
- Rabbit polyclonal to TGF beta 2
- Suitable for: IHC, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-TGF beta 2 antibody
See all TGF beta 2 primary antibodies -
Description
Rabbit polyclonal to TGF beta 2 -
Host species
Rabbit -
Specificity
Reacts specifically with human 48 kDa TGF beta 2 protein. -
Tested applications
Suitable for: IHC, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: a wide range of other species -
Immunogen
Synthetic peptide derived from the N terminal domain of Human TGF beta 2.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab80059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC |
1/100 - 1/500.
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WB | (1) |
1/500 - 1/5000. Predicted molecular weight: 47 kDa.
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Notes |
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IHC
1/100 - 1/500. |
WB
1/500 - 1/5000. Predicted molecular weight: 47 kDa. |
Target
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Function
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. -
Involvement in disease
A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
Loeys-Dietz syndrome 4
Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features. -
Sequence similarities
Belongs to the TGF-beta family. -
Post-translational
modificationsThe precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 7040 Human
- Entrez Gene: 7042 Human
- Entrez Gene: 7043 Human
- Omim: 190220 Human
- SwissProt: P01137 Human
- SwissProt: P10600 Human
- SwissProt: P61812 Human
- Unigene: 133379 Human
see all -
Alternative names
- BSC-1 cell growth inhibitor antibody
- BSC1 cell growth inhibitor antibody
- Cetermin antibody
see all
Datasheets and documents
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Datasheet download
References (2)
ab80059 has been referenced in 2 publications.
- Chuo D et al. LncRNA MIR503HG is downregulated in Han Chinese with colorectal cancer and inhibits cell migration and invasion mediated by TGF-ß2. Gene 713:143960 (2019). PubMed: 31278965
- Nicola T et al. Hypoxia-induced inhibition of lung development is attenuated by the peroxisome proliferator-activated receptor-{gamma} agonist rosiglitazone. Am J Physiol Lung Cell Mol Physiol 301:L125-34 (2011). WB ; Mouse . PubMed: 21531777