Overview

  • Product name
  • Description
    Rabbit polyclonal to TGF beta 2
  • Host species
    Rabbit
  • Specificity
    ab81076 antibody reacts with the precursor and mature form of TGF beta 2 and to a lesser extent TGF beta 3, but does not cross react with TGF beta 1.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide derived from the internal region of human TGF beta 2

  • Positive control
    • Placenta

Properties

Applications

Our Abpromise guarantee covers the use of ab81076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol, by boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
    • Involvement in disease
      A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.
      Loeys-Dietz syndrome 4
      Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). NSAD is a frequently asymptomatic but potentially lethal disease characterized by thoracic aortic aneurysms and dissections without additional syndromic features.
    • Sequence similarities
      Belongs to the TGF-beta family.
    • Post-translational
      modifications
      The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • BSC-1 cell growth inhibitor antibody
      • BSC1 cell growth inhibitor antibody
      • Cetermin antibody
      • G-TSF antibody
      • Glioblastoma-derived T-cell suppressor factor antibody
      • GTSF antibody
      • LAP antibody
      • Latency-associated peptide antibody
      • MGC116892 antibody
      • MGF antibody
      • Milk growth factor antibody
      • Polyergin antibody
      • TGF-beta-2 antibody
      • TGF-beta2 antibody
      • TGFB2 antibody
      • TGFB2_HUMAN antibody
      • Transforming growth factor beta 2 antibody
      see all

    Images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human placenta tissue, using 1/100 ab81076.

    References

    ab81076 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab81076.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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