FunctionTranscriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Tissue specificityWidely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
Sequence similaritiesBelongs to the TALE/TGIF homeobox family. Contains 1 homeobox DNA-binding domain.
Post-translational modificationsThe C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.
Cellular localizationNucleus. Excluded from nucleoli.