Anti-TGF-beta receptor-associated protein 1 antibody (ab122468)

Overview

  • Product name
    Anti-TGF-beta receptor-associated protein 1 antibody
    See all TGF-beta receptor-associated protein 1 primary antibodies
  • Description
    Rabbit polyclonal to TGF-beta receptor-associated protein 1
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human TGF-beta receptor-associated protein 1 aa 712-807 (internal sequence).
    Sequence:

    RQQLFHTLLAIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTW SVQLLCPFLMGAMRDSIHARRTMQVALGLARSENLIYTYDKMKLKG

  • Positive control
    • Human pancreas tissue; RT 4 and U 251 MG cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab122468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function
    Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
  • Sequence similarities
    Belongs to the TRAP1 family.
    Contains 1 CNH domain.
  • Cellular localization
    Cytoplasm. Colocalizes with TGF-beta receptors in the absence of signaling.
  • Information by UniProt
  • Database links
  • Alternative names
    • TGF-beta receptor-associated protein 1 antibody
    • TGFA1_HUMAN antibody
    • Tgfbrap1 antibody
    • Transforming growth factor-beta receptor-associated protein 1 antibody
    • TRAP-1 antibody
    • TRAP1 antibody
    • VPS3 antibody
    see all

Images

  • ab122468, at 1/10 dilution, staining TGF-beta receptor-associated protein 1 in paraffin-embedded Human pancreas tissue by Immunohistochemistry.

  • All lanes : Anti-TGF-beta receptor-associated protein 1 antibody (ab122468) at 1/250 dilution

    Lane 1 : RT 4 cell lysate
    Lane 2 : U 251 MG cell lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver tissue lysate
    Lane 5 : Human tonsil tissue lysate

    Developed using the ECL technique

References

ab122468 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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