Overview

  • Product nameAnti-TGFBI antibody
    See all TGFBI primary antibodies
  • Description
    Mouse polyclonal to TGFBI
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1 - 683 of Human TGFBI (AAH00097)

  • Positive control
    • Liver or pancreas tissue lysate; HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 75 kDa.

Target

  • FunctionBinds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation.
  • Tissue specificityHighly expressed in the corneal epithelium.
  • Involvement in diseaseDefects in TGFBI are the cause of epithelial basement membrane corneal dystrophy (EBMD) [MIM:121820]; also known as Cogan corneal dystrophy or map-dot-fingerprint type corneal dystrophy. EBMD is a bilateral anterior corneal dystrophy characterized by grayish epithelial fingerprint lines, geographic map-like lines, and dots (or microcysts) on slit-lamp examination. Pathologic studies show abnormal, redundant basement membrane and intraepithelial lacunae filled with cellular debris. Although this disorder usually is not considered to be inherited, families with autosomal dominant inheritance have been identified.
    Defects in TGFBI are the cause of corneal dystrophy Groenouw type 1 (CDGG1) [MIM:121900]; also known as corneal dystrophy granular type. Inheritance is autosomal dominant. Corneal dystrophies show progressive opacification of the cornea leading to severe visual handicap.
    Defects in TGFBI are the cause of corneal dystrophy lattice type 1 (CDL1) [MIM:122200]. Inheritance is autosomal dominant.
    Defects in TGFBI are a cause of corneal dystrophy Thiel-Behnke type (CDTB) [MIM:602082]; also known as corneal dystrophy of Bowman layer type 2 (CDB2).
    Defects in TGFBI are the cause of Reis-Buecklers corneal dystrophy (CDRB) [MIM:608470]; also known as corneal dystrophy of Bowman layer type 1 (CDB1).
    Defects in TGFBI are the cause of lattice corneal dystrophy type 3A (CDL3A) [MIM:608471]. CDL3A clinically resembles to lattice corneal dystrophy type 3, but differs in that its age of onset is 70 to 90 years. It has an autosomal dominant inheritance pattern.
    Defects in TGFBI are the cause of Avellino corneal dystrophy (ACD) [MIM:607541]. ACD could be considered a variant of granular dystrophy with a significant amyloidogenic tendency. Inheritance is autosomal dominant.
  • Sequence similaritiesContains 1 EMI domain.
    Contains 4 FAS1 domains.
  • Post-translational
    modifications
    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • Cellular localizationSecreted > extracellular space > extracellular matrix. May be associated both with microfibrils and with the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • RGD containing collagen associated protein antibody
    • AI181842 antibody
    • AI747162 antibody
    • Beta ig antibody
    • Beta ig h3 antibody
    • Beta ig-h3 antibody
    • BGH3_HUMAN antibody
    • Big h3 antibody
    • BIGH3 antibody
    • CDB1 antibody
    • CDG2 antibody
    • CDGG1 antibody
    • CSD antibody
    • CSD1 antibody
    • CSD2 antibody
    • CSD3 antibody
    • EBMD antibody
    • Kerato epithelin antibody
    • Kerato-epithelin antibody
    • LCD1 antibody
    • MGC150270 antibody
    • RGD CAP antibody
    • RGD-CAP antibody
    • RGD-containing collagen-associated protein antibody
    • TGFBI antibody
    • TGFBI transforming growth factor, beta induced, 68kDa antibody
    • Transforming growth factor beta induced protein ig h3 antibody
    • Transforming growth factor-beta-induced protein ig-h3 antibody
    see all

Anti-TGFBI antibody images

  • Anti-TGFBI antibody (ab89062) at 1 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 75 kDa
  • Anti-TGFBI antibody (ab89062) at 1 µg/ml + Human pancreas tissue lysate at 50 µg

    Predicted band size : 75 kDa
  • Anti-TGFBI antibody (ab89062) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 75 kDa
  • All lanes : Anti-TGFBI antibody (ab89062) at 1 µg/ml

    Lane 1 : TGFBI-transfected 293T cell lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 75 kDa
    Observed band size : 75 kDa

References for Anti-TGFBI antibody (ab89062)

This product has been referenced in:
  • Bateman NW  et al. Defining central themes in breast cancer biology by differential proteomics: conserved regulation of cell spreading and focal adhesion kinase. J Proteome Res 9:5311-24 (2010). Read more (PubMed: 20681588) »

See 1 Publication for this product

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