Overview

  • Product nameAnti-THAP1 antibody
    See all THAP1 primary antibodies
  • Description
    Rabbit polyclonal to THAP1
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human THAP1 protein (NP_060575.1)

  • Positive control
    • Jurkat cell lysate, transfected 293T cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab118368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 25 kDa.
IP Use at an assay dependent dilution.

Target

  • FunctionDNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
  • Involvement in diseaseDefects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
  • Sequence similaritiesBelongs to the THAP1 family.
    Contains 1 THAP-type zinc finger.
  • Cellular localizationNucleus > nucleoplasm. Nucleus > PML body.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4833431A01Rik antibody
    • FLJ10477 antibody
    • MGC33014 antibody
    • Nuclear proapoptotic factor antibody
    • THAP 1 antibody
    • THAP domain containing apoptosis associated protein 1 antibody
    • THAP domain containing protein 1 antibody
    • THAP domain protein 1 antibody
    • THAP domain-containing protein 1 antibody
    • Thap1 antibody
    • THAP1_HUMAN antibody
    see all

Anti-THAP1 antibody images

  • Anti-THAP1 antibody (ab118368) at 1/1000 dilution + Jurkat cell lystate at 50 µg

    Predicted band size : 25 kDa
  • All lanes : Anti-THAP1 antibody (ab118368) at 1/1000 dilution

    Lane 1 : THAP1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 25 kDa
  • Immunoprecipitation of THAP1 transfected lysate using ab118368 and Protein A Magnetic Bead. Detected using another antibody to THAP1.

References for Anti-THAP1 antibody (ab118368)

ab118368 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"