Overview

  • Product nameAnti-THAP1 antibody
    See all THAP1 primary antibodies
  • Description
    Mouse monoclonal to THAP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-214 of Human THAP1

Properties

Applications

Our Abpromise guarantee covers the use of ab57481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
    • Involvement in diseaseDefects in THAP1 are the cause of dystonia type 6 (DYT6) [MIM:602629]. DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions.
    • Sequence similaritiesBelongs to the THAP1 family.
      Contains 1 THAP-type zinc finger.
    • Cellular localizationNucleus > nucleoplasm. Nucleus > PML body.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4833431A01Rik antibody
      • FLJ10477 antibody
      • MGC33014 antibody
      • Nuclear proapoptotic factor antibody
      • THAP 1 antibody
      • THAP domain containing apoptosis associated protein 1 antibody
      • THAP domain containing protein 1 antibody
      • THAP domain protein 1 antibody
      • THAP domain-containing protein 1 antibody
      • Thap1 antibody
      • THAP1_HUMAN antibody
      see all

    Anti-THAP1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57481 THAP1 antibody at 1ug/ml. Predicted band size of immunogen is 50 kDa

    References for Anti-THAP1 antibody (ab57481)

    ab57481 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. The immunogen sequence for this product is as below. Immunogen: THAP1 (1 a.a. ~ 214 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence (without GST tag): ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"