FunctionTranscriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.
Sequence similaritiesBelongs to the THAP11 family. Contains 1 THAP-type zinc finger.
Cellular localizationNucleus. Cytoplasm. May be regulated by shuttling of the protein between the cytoplasm and nucleus.