The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.3 - 3 µg/ml. Predicted molecular weight: 73 kDa.
FunctionPlays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
Sequence similaritiesBelongs to the themis family.
Post-translational modificationsPhosphorylated on Tyr residues quickly after TCR stimulation.