Overview

  • Product nameThioridazine hydrochloride
  • Description
    Dopamine receptor antagonist
  • Alternative names
    • THIO
  • Biological descriptionDopamine receptor antagonist (Ki values are 16 (D2), 10 (D1), 7.8 (D3), and 31 (D4) nM). Also inhibits CYP2D6 (IC50 = 2.7 μM). Antipsychotic. Displays antituberculosis/ drug-resistant tuberculosis properties.
  • Purity> 99%

Properties

    References for Thioridazine hydrochloride (ab120580)

    This product has been referenced in:
    • van Soolingen D  et al. The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis. PLoS One 5: (2010). Read more (PubMed: 20844587) »
    • Daniel WA  et al. Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants. Br J Pharmacol 131:287-95 (2000). Read more (PubMed: 10991922) »
    • Shin JG  et al. Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos 27:1078-84 (1999). Read more (PubMed: 10460810) »

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