Biological descriptionDopamine receptor antagonist (Ki values are 16 (D2), 10 (D1), 7.8 (D3), and 31 (D4) nM). Also inhibits CYP2D6 (IC50 = 2.7 μM). Antipsychotic. Displays antituberculosis/ drug-resistant tuberculosis properties.
Chemical name10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM, in ethanol to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Thioridazine hydrochloride (ab120580)
This product has been referenced in:
van Soolingen D et al. The antipsychotic thioridazine shows promising therapeutic activity in a mouse model of multidrug-resistant tuberculosis. PLoS One5: (2010).
Read more (PubMed: 20844587) »
Daniel WA et al. Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants. Br J Pharmacol131:287-95 (2000).
Read more (PubMed: 10991922) »
Shin JG et al. Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos27:1078-84 (1999).
Read more (PubMed: 10460810) »