Anti-Thrombin Receptor antibody (ab111976)

Overview

  • Product nameAnti-Thrombin Receptor antibody
    See all Thrombin Receptor primary antibodies
  • Description
    Goat polyclonal to Thrombin Receptor
  • Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    TRARRPESKATNAT

    by a Cysteine residue linker, corresponding to internal sequence amino acids 24-37 of Human Thrombin Receptor (NP_001983.2).

  • Positive control
    • HeLa lysate; Human liver tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab111976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 47 kDa.
IHC-P Use a concentration of 2.5 µg/ml.
ELISA 1/3200.

Target

  • FunctionHigh affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
  • Tissue specificityPlatelets and vascular endothelial cells.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
    Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CF2R antibody
    • Coagulation factor II (thrombin) receptor antibody
    • Coagulation factor II receptor antibody
    • F2R antibody
    • HTR antibody
    • PAR 1 antibody
    • PAR-1 antibody
    • PAR1 antibody
    • PAR1_HUMAN antibody
    • Protease activated receptor 1 antibody
    • Proteinase activated receptor 1 antibody
    • Proteinase-activated receptor 1 antibody
    • Thrombin receptor antibody
    • TR antibody
    see all

Anti-Thrombin Receptor antibody images

  • ab111976, at 2.5µg/ml, staining Thrombin Receptor in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.
  • Anti-Thrombin Receptor antibody (ab111976) at 0.5 µg/ml + HeLa lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 47 kDa

References for Anti-Thrombin Receptor antibody (ab111976)

ab111976 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The Uniprot http://www.uniprot.org/uniprot/P25116 database shows, the active part of protein "human Proteinase-activated receptor 1" has amino acid sequence between 42-425, so antibodies specific to this ...

Read More

thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this h...

Read More

Thank you for your reply.

Are the platelets from Human? This provides us with vital information for monitoring product quality.

I appreciate the time you have spent in the laboratory andI would be pleased to offer you a free of charge...

Read More

Thank you for contacting us. I am sorry to hear that this antibody is not providing satisfactory results.

The details provided will enable us to investigate this case and will provide us with vital information for monitoring product quality. Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"