Anti-Thrombin Receptor antibody (ab87647)

Overview

  • Product nameAnti-Thrombin Receptor antibody
    See all Thrombin Receptor primary antibodies
  • Description
    Goat polyclonal to Thrombin Receptor
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide with sequence

    C-TRARRPESKATNAT

    , corresponding to internal sequence (near the N terminus) amino acids 24 - 37 of Human Thrombin Receptor, with a Cysteine residue linker (NP_001983.2.)

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab87647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 47 kDa.

Target

  • FunctionHigh affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
  • Tissue specificityPlatelets and vascular endothelial cells.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
    Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CF2R antibody
    • Coagulation factor II (thrombin) receptor antibody
    • Coagulation factor II receptor antibody
    • F2R antibody
    • HTR antibody
    • PAR 1 antibody
    • PAR-1 antibody
    • PAR1 antibody
    • PAR1_HUMAN antibody
    • Protease activated receptor 1 antibody
    • Proteinase activated receptor 1 antibody
    • Proteinase-activated receptor 1 antibody
    • Thrombin receptor antibody
    • TR antibody
    see all

Anti-Thrombin Receptor antibody images

  • Anti-Thrombin Receptor antibody (ab87647) at 0.5 µg/ml + HeLa cell lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 47 kDa
    Observed band size : 47 kDa

References for Anti-Thrombin Receptor antibody (ab87647)

ab87647 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry regarding ab87647.

I can confirm that the immunogen used to raise is a synthetic peptide with sequence C-TRARRPESKATNAT, corresponding to internal sequence (near the N terminus) amino acids 24 - 37 of Human Thrombin...

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The Uniprot http://www.uniprot.org/uniprot/P25116 database shows, the active part of protein "human Proteinase-activated receptor 1" has amino acid sequence between 42-425, so antibodies specific to this ...

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