Anti-Thrombomodulin antibody [B-A35] (FITC) (ab27396)

Overview

  • Product nameAnti-Thrombomodulin antibody [B-A35] (FITC)
    See all Thrombomodulin primary antibodies
  • Description
    Mouse monoclonal [B-A35] to Thrombomodulin (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    TF1 cell line

  • Positive control
    • Monocytes

Properties

Applications

Our Abpromise guarantee covers the use of ab27396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use 10µl for 106 cells or 100 µl of whole blood.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionThrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
    • Tissue specificityEndothelial cells are unique in synthesizing thrombomodulin.
    • Involvement in diseaseDefects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBD) [MIM:188040]. A hemostatic disorder characterized by a tendency to thrombosis.
      Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6) [MIM:612926]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
    • Sequence similaritiesContains 1 C-type lectin domain.
      Contains 6 EGF-like domains.
    • Post-translational
      modifications
      N-glycosylated.
      The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AHUS 6 antibody
      • AHUS6 antibody
      • BDCA 3 antibody
      • BDCA3 antibody
      • CD 141 antibody
      • CD141 antibody
      • CD141 antigen antibody
      • Fetomodulin antibody
      • Thbd antibody
      • THPH12 antibody
      • THRM antibody
      • Thrombomodulin antibody
      • TM antibody
      • TRBM_HUMAN antibody
      see all

    Anti-Thrombomodulin antibody [B-A35] (FITC) images

    • A typical staining pattern with ab27396 of monocytes

    References for Anti-Thrombomodulin antibody [B-A35] (FITC) (ab27396)

    ab27396 has not yet been referenced specifically in any publications.

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    DISCOUNT CODE: XXXXXXX Expiration date: [23/03/2012] I am very pleased to hear you would like to accept our offer and test ab27396 in ICC/IF in Human. This code will give you 1 free PRIMARY ANTIBODY before the expiration date. To redeem this off...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"