Anti-Thrombopoietin antibody (ab115679)

Overview

  • Product nameAnti-Thrombopoietin antibody
    See all Thrombopoietin primary antibodies
  • Description
    Rabbit polyclonal to Thrombopoietin
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide:

    KLLRDSHVLHSRLSQC

    conjugated to KLH, corresponding to amino acids 35-50 of Human Thrombopoietin (NP_000451.1).

  • Positive control
    • Human Spleen tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab115679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionLineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • Involvement in diseaseDefects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
  • Sequence similaritiesBelongs to the EPO/TPO family.
  • DomainTwo-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C mpl ligand antibody
    • C-mpl ligand antibody
    • Megakaryocyte colony stimulating factor antibody
    • Megakaryocyte colony-stimulating factor antibody
    • Megakaryocyte growth and development factor antibody
    • Megakaryocyte stimulating factor antibody
    • MGC163194 antibody
    • MGDF antibody
    • MKCSF antibody
    • ML antibody
    • MPL ligand antibody
    • MPLLG antibody
    • Myeloproliferative leukemia virus oncogene ligand antibody
    • Prepro thrombopoietin antibody
    • THCYT1 antibody
    • THPO antibody
    • Thrombopoietin antibody
    • Thrombopoietin nirs variant 1 antibody
    • TPO antibody
    • TPO_HUMAN antibody
    see all

Anti-Thrombopoietin antibody images

  • ab115679, at 10µg/ml, staining Thrombopoietin in Formalin-fixed, Paraffin-embedded Human Spleen tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-Thrombopoietin antibody (ab115679)

ab115679 has not yet been referenced specifically in any publications.

Product Wall

For ab112238: DISCOUNT CODE: ***
For ab115679: DISCOUNT CODE: ***
Expiration date: November 19, 2012

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