Anti-Thrombopoietin antibody [BDI321] (ab31425)

Overview

  • Product name
    Anti-Thrombopoietin antibody [BDI321]
    See all Thrombopoietin primary antibodies
  • Description
    Mouse monoclonal [BDI321] to Thrombopoietin
  • Specificity
    This antibody recognizes recombinant thrombopoietin: 100%: 0%; TPO (14–29): ~80%; rEPO: 0%; ACTH (1–39): 0%; Calcitonin: 0%; Insulin: 0%; Insulin like Growth Factor 1: 0%; Insulin like Growth Factor 2: 0%; Parathyroid hormone: 0%. The clone number has been updated from (1.B.6) to (BDI321) both clone numbers name the same antibody clone.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    LTARLTLSSPAPPACD

    , corresponding to amino acids 14-29 of Human Thrombopoietin.

Properties

Applications

Our Abpromise guarantee covers the use of ab31425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA (indirect): 1/30 - 1/100.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 38 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
    • Involvement in disease
      Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
    • Sequence similarities
      Belongs to the EPO/TPO family.
    • Domain
      Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • C mpl ligand antibody
      • C-mpl ligand antibody
      • Megakaryocyte colony stimulating factor antibody
      • Megakaryocyte colony-stimulating factor antibody
      • Megakaryocyte growth and development factor antibody
      • Megakaryocyte stimulating factor antibody
      • MGC163194 antibody
      • MGDF antibody
      • MKCSF antibody
      • ML antibody
      • MPL ligand antibody
      • MPLLG antibody
      • Myeloproliferative leukemia virus oncogene ligand antibody
      • Prepro thrombopoietin antibody
      • THCYT1 antibody
      • THPO antibody
      • Thrombopoietin antibody
      • Thrombopoietin nirs variant 1 antibody
      • TPO antibody
      • TPO_HUMAN antibody
      see all

    References

    ab31425 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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