Anti-Thrombopoietin antibody [BDI321] (ab31425)

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Overview

  • Product name
    Anti-Thrombopoietin antibody [BDI321]
    See all Thrombopoietin primary antibodies
  • Description
    Mouse monoclonal [BDI321] to Thrombopoietin
  • Host species
    Mouse
  • Specificity
    This antibody recognizes recombinant thrombopoietin: 100%: 0%; TPO (14–29): ~80%; rEPO: 0%; ACTH (1–39): 0%; Calcitonin: 0%; Insulin: 0%; Insulin like Growth Factor 1: 0%; Insulin like Growth Factor 2: 0%; Parathyroid hormone: 0%. The clone number has been updated from (1.B.6) to (BDI321) both clone numbers name the same antibody clone.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    LTARLTLSSPAPPACD

    , corresponding to amino acids 14-29 of Human Thrombopoietin.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

Properties

Applications

Our Abpromise guarantee covers the use of ab31425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA (indirect): 1/30 - 1/100.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 38 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Function
      Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
    • Involvement in disease
      Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
    • Sequence similarities
      Belongs to the EPO/TPO family.
    • Domain
      Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
      see all
    • Alternative names
      • C mpl ligand antibody
      • C-mpl ligand antibody
      • Megakaryocyte colony stimulating factor antibody
      • Megakaryocyte colony-stimulating factor antibody
      • Megakaryocyte growth and development factor antibody
      • Megakaryocyte stimulating factor antibody
      • MGC163194 antibody
      • MGDF antibody
      • MKCSF antibody
      • ML antibody
      • MPL ligand antibody
      • MPLLG antibody
      • Myeloproliferative leukemia virus oncogene ligand antibody
      • Prepro thrombopoietin antibody
      • THCYT1 antibody
      • THPO antibody
      • Thrombopoietin antibody
      • Thrombopoietin nirs variant 1 antibody
      • TPO antibody
      • TPO_HUMAN antibody
      see all

    References

    ab31425 has not yet been referenced specifically in any publications.

    Publishing research using ab31425? Please let us know so that we can cite the reference in this datasheet.

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