Anti-Thrombopoietin antibody (Biotin) (ab84445)

Overview

  • Product name
    Anti-Thrombopoietin antibody (Biotin)
    See all Thrombopoietin primary antibodies
  • Description
    Goat polyclonal to Thrombopoietin (Biotin)
  • Conjugation
    Biotin
  • Tested applications
    Suitable for: ELISA, Sandwich ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant Human full length protein

Properties

Applications

Our Abpromise guarantee covers the use of ab84445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use a concentration of 0.25 - 1 µg/ml. Detection limit for recombinant Human Thrombopoietin: 0.2 - 0.4 ng/well.
Sandwich ELISA Use a concentration of 0.25 - 1 µg/ml. Use as detection antibody with recommended pair. Detection of recombinant Human Thrombopoietin: 0.2 - 0.4 ng/well.
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 38 kDa. Detection limit for recombinant Human Thrombopoietin: 1.5 - 3.0 ng/lane, under reducing or non-reducing conditions.

Target

  • Function
    Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • Involvement in disease
    Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
  • Sequence similarities
    Belongs to the EPO/TPO family.
  • Domain
    Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C mpl ligand antibody
    • C-mpl ligand antibody
    • Megakaryocyte colony stimulating factor antibody
    • Megakaryocyte colony-stimulating factor antibody
    • Megakaryocyte growth and development factor antibody
    • Megakaryocyte stimulating factor antibody
    • MGC163194 antibody
    • MGDF antibody
    • MKCSF antibody
    • ML antibody
    • MPL ligand antibody
    • MPLLG antibody
    • Myeloproliferative leukemia virus oncogene ligand antibody
    • Prepro thrombopoietin antibody
    • THCYT1 antibody
    • THPO antibody
    • Thrombopoietin antibody
    • Thrombopoietin nirs variant 1 antibody
    • TPO antibody
    • TPO_HUMAN antibody
    see all

References

ab84445 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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