Overview

  • Product name
    Anti-Thymidine Kinase 2 antibody
  • Description
    Rabbit polyclonal to Thymidine Kinase 2
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A KLH conjugated synthetic peptide selected within aa 1~100 of human Thymidine Kinase 2.

  • Positive control
    • HepG2 cell lysate and mouse liver tissue lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab38302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa).

Target

  • Function
    Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
  • Tissue specificity
    Predominantly expressed in liver, pancreas, muscle, and brain.
  • Involvement in disease
    Defects in TK2 are a cause of mitochondrial DNA depletion syndrome type 2 (MTDPS2) [MIM:609560]. A disorder characterized primarily by childhood onset of muscle weakness associated with depletion of mtDNA in skeletal muscle. There is wide clinical variability; some patients have onset in infancy and show a rapidly progressive course with early death due to respiratory failure, whereas others have later onset of a slowly progressive myopathy.
  • Sequence similarities
    Belongs to the DCK/DGK family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.7.1.21 antibody
    • KITM_HUMAN antibody
    • mitochondrial antibody
    • Mt TK antibody
    • Mt-TK antibody
    • Thymidine kinase 2 antibody
    • Thymidine kinase 2 mitochondrial antibody
    • TK2 antibody
    see all

Images

  • All lanes : Anti-Thymidine Kinase 2 antibody (ab38302) at 1/100 dilution

    Lane 1 : HepG2 cell lysate
    Lane 2 : mouse liver tissue lysate


    Predicted band size : 31 kDa
    Observed band size : 31 kDa

References

ab38302 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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