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Anti-Thyroglobulin antibody [12G9] (ab1983)

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Overview

Product name

Anti-Thyroglobulin antibody [12G9]
See all Thyroglobulin products (20) ...

Description

Mouse monoclonal [12G9] to Thyroglobulin

Specificity

This antibody does not interfere with anti-thyroglobulin autoantibodies.

Tested applications

ELISA, IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Rat, Cow, Cat, Dog, Human, Pig

Immunogen

Thyroglobulin from human thyroid gland.

General notes

Concentration varies from lot to lot and can be provided on request.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein G purified

Purification notes

Purity is tested by electrophoresis.

Clonality

Monoclonal

Clone number

12G9

Myeloma

Sp2/0

Isotype

IgM

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

  • ShowHide

    IHC-P

     IHC-P: Use at an assay d...Read more →

    IHC-P: Use at an assay dependent dilution. (PubMed: 20362088)

Target

Function

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Tissue specificity

Thyroid gland specific.

Involvement in disease

Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.

Post-translational
modifications

Sulfated tyrosines are desulfated during iodination.

Cellular localization

Secreted.

Target information above from: UniProt accessionP01266 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AITD 3 antibody
  • AITD3 antibody
  • hTG antibody
  • TDH3 antibody
  • TG antibody
  • Tgn antibody
  • THYG_HUMAN antibody
  • Thyroglobulin antibody
see all

References for Anti-Thyroglobulin antibody [12G9] (ab1983)

This product has been referenced in:

See 1 publication for this product

Publishing research using ab1983? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"