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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-Thyroglobulin antibody [12G9]
See all Thyroglobulin products (20) ...
Description
Mouse monoclonal [12G9] to Thyroglobulin
Specificity
This antibody does not interfere with anti-thyroglobulin autoantibodies.
Tested applications
ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Cow, Cat, Dog, Human, Pig
Immunogen
Thyroglobulin from human thyroid gland.
General notes
Concentration varies from lot to lot and can be provided on request.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
Purity is tested by electrophoresis.
Clonality
Monoclonal
Clone number
12G9
Myeloma
Sp2/0
Isotype
IgM
Research areas
Cancer >> Tumor biomarkers >> Globulins
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1983 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
IHC-P: Use at an assay dependent dilution. (PubMed: 20362088)
Target
Function
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Tissue specificity
Thyroid gland specific.
Involvement in disease
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
Post-translational
modifications
Sulfated tyrosines are desulfated during iodination.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01266
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
Database links
- Entrez Gene: 280706 Cow
- Entrez Gene: 7038 Human
- Entrez Gene: 21819 Mouse
- Entrez Gene: 24826 Rat
- Omim: 188450 Human
- SwissProt: P01267 Cow
- SwissProt: P01266 Human
- SwissProt: O08710 Mouse
see all
References for Anti-Thyroglobulin antibody [12G9] (ab1983)
This product has been referenced in:
- Farnum CEet al. Analyzing primary cilia by multiphoton microscopy. Methods Cell Biol 94:117-35 (2009). IHC-P; Mouse, Rat.Read more (PubMed: 20362088) »
See 1 publication for this product
Publishing research using ab1983? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"