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Product Name
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Thyroglobulin antibody [12G9]
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See all Thyroglobulin antibodies (19)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [12G9] to Thyroglobulin
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Immunogen
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Thyroglobulin from human thyroid gland.
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Reacts with
(species key)
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Hu, Ms, Rat, Cat, Cow, Dog, Pig
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Specificity
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This antibody does not interfere with anti-thyroglobulin autoantibodies.
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Tumor biomarkers >> Globulins
Signal Transduction >> Growth Factors/Hormones >> Hormones
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Relevance
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Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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12G9
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Myeloma
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Sp2/0
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Isotype
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IgM
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purity is tested by electrophoresis.
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Form
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Liquid
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Concentration
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5.000 mg/ml
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Storage instructions
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Store at +4°C.
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Notes
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Concentration varies from lot to lot and can be provided on request.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Thyroglobulin antibody [12G9] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Thyroglobulin
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