Recombinant
RabMAb

Anti-Thyroglobulin antibody [EPR9730(IHC)] (ab168344)

Overview

  • Product name
    Anti-Thyroglobulin antibody [EPR9730(IHC)]
    See all Thyroglobulin primary antibodies
  • Description
    Rabbit monoclonal [EPR9730(IHC)] to Thyroglobulin
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
    Unsuitable for: IP or WB
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Recombinant full length protein corresponding to Human Thyroglobulin aa 1-2800.
    Database link: P01266

  • Positive control
    • Human thyroid gland follicular and papillary carcinoma tissues; TT cells.
  • General notes

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, 0.05% BSA
  • Purity
    Tissue culture supernatant
  • Clonality
    Monoclonal
  • Clone number
    EPR9730(IHC)
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab168344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/250 - 1/500.
IHC-P 1/250 - 1/500.
  • Application notes
    Is unsuitable for IP or WB.
  • Target

    • Function
      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • Tissue specificity
      Thyroid gland specific.
    • Involvement in disease
      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • Sequence similarities
      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • Post-translational
      modifications
      Sulfated tyrosines are desulfated during iodination.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    Images

    • ab168344 showing +ve staining in Human thyroid gland tissue.

    • Immunohistochemical analysis of paraffin-embedded Human thyroid gland papillary carcinoma tissue labelingThyroglobulin with ab168344 at 1/250 dilution.

    • Immunohistochemical analysis of paraffin-embedded Human thyroid gland follicular carcinoma tissue labeling Thyroglobulin with ab168344 at 1/250 dilution.

    • ab168344 showing -ve staining in Human skeletal muscle tissue.
    • ab168344 showing -ve staining in Human normal kidney tissue.
    • ab168344 showing -ve staining in Human normal tonsil tissue.
    • ab168344 showing -ve staining in Human prostate hyperplasia tissue.
    • Immunofluorescent analysis of TT cells labeling Thyroglobulin with ab168344 at 1/250 dilution.

    References

    ab168344 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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