Anti-Thyroglobulin antibody [SPM517], prediluted (ab52134)

Overview

  • Product name
    Anti-Thyroglobulin antibody [SPM517], prediluted
    See all Thyroglobulin primary antibodies
  • Description
    Mouse monoclonal [SPM517] to Thyroglobulin, prediluted
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human thyroglobulin

  • Positive control
    • IHC: Human thyroid tissue.

Properties

  • Form
    Prediluted
  • Storage instructions
    Shipped at 4°C. Store at +4°C. Do Not Freeze.
  • Storage buffer
    pH: 7.60
    Preservative: 0.1% Sodium azide
    Constituents: 1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Monoclonal
  • Clone number
    SPM517
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab52134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Ready-to-use for 30 min at RT. Staining of formalin-fixed tissues requires no pretreatment


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
    • Tissue specificity
      Thyroid gland specific.
    • Involvement in disease
      Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
      Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
    • Sequence similarities
      Belongs to the type-B carboxylesterase/lipase family.
      Contains 11 thyroglobulin type-1 domains.
    • Post-translational
      modifications
      Sulfated tyrosines are desulfated during iodination.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • AITD 3 antibody
      • AITD3 antibody
      • hTG antibody
      • TDH3 antibody
      • Tg antibody
      • TGN antibody
      • THYG_HUMAN antibody
      • Thyroglobulin antibody
      see all

    Images

    • Formulin-fixed, paraffin-embedded human thyroid tissue stained for Thyroglobulin using ab52134 in immunohistochemical analysis.

    • ab52134, ready to use for staining human thyroglobulin in thyroid tissue using Immunohistochemsitry, Formalin fixed Paraffin embedded tissue.

    References

    ab52134 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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