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Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer Preservative: None
Constituents: 2% Sucrose, PBS
Concentration information loading...
Purity Immunogen affinity purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
Use a concentration of 4 - 8 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Function Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Involvement in disease Hypothyroidism, congenital, non-goitrous, 6
Sequence similarities Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Cellular localization Nucleus.
Information by UniProt
Anti-Thyroid Hormone Receptor alpha 1+2 antibody images
Western blot - Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)
Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab105003) at 0.5 µg/ml + Jurkat cell lysate at 10 µg Predicted band size : 55 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)
ab105003, at 4µg/ml, staining Thyroid Hormone Receptor alpha 1 + 2, in Human squamous epithelial cells by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Magnification 400x.
References for Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)
This product has been referenced in:
et al. A TNF Variant that Associates with Susceptibility to Musculoskeletal Disease Modulates Thyroid Hormone Receptor Binding to Control Promoter Activation. PLoS One 8:e76034 (2013).
Read more (PubMed: 24069456) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"