Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab15543)

Overview

  • Product nameAnti-Thyroid Hormone Receptor alpha 1+2 antibodySee all Thyroid Hormone Receptor alpha 1+2 primary antibodies ...
  • Description
    Rabbit polyclonal to Thyroid Hormone Receptor alpha 1+2
  • Specificityab15543 reacts with both Thyroid Hormone Receptor alpha 1 and Thyroid Hormone Receptor alpha 2.
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Pig
  • Immunogen

    Synthetic peptide: GDETQWPNGVKRKRKNSQCS, corresponding to amino acids 13-32 of Human Thyroid Hormone Receptor alpha 1.

  • Positive control
    • Colon carcinoma.
  • General notes


    Thyroid receptors have expression patterns that vary according to tissue and developmental stage. Almost all tissues express the alpha-1, alpha-2 and beta-1 isoforms, but beta-2 is synthesized almost exclusively in hypothalamus, anterior pituitary and developing ear. Receptor alpha-1 is the first isoform expressed in the conceptus.

Properties

Applications

Our Abpromise guarantee covers the use of ab15543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
  • Application notesIHC-P: 1/100. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNuclear hormone receptor. High affinity receptor for triiodothyronine.
    • Involvement in diseaseDefects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.
    • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • Cellular localizationNucleus.
    • Target information above from: UniProt accession P10827 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • AR7 antibody
      • Avian erythroblastic leukemia viral (v erb a) oncogene homolog antibody
      • c ERBA 1 antibody
      • c ERBA ALPHA 2 antibody
      • C erbA alpha antibody
      • c-erbA-1 antibody
      • C-erbA-alpha antibody
      • cerbA protein antibody
      • cerbAalpha antibody
      • EAR 7 antibody
      • EAR 7.1 antibody
      • EAR 7.2 antibody
      • EAR-7 antibody
      • EAR7 antibody
      • ERB T 1 antibody
      • ERBA 1 antibody
      • ERBA ALPHA antibody
      • ERBA antibody
      • ERBA related 7 antibody
      • ERBA1 antibody
      • Erythroblastic leukemia viral (v erb a) oncogene homolog avian antibody
      • MGC000261 antibody
      • MGC43240 antibody
      • NR1A 1 antibody
      • Nr1a1 antibody
      • Nuclear receptor subfamily 1 group A member 1 antibody
      • Oncogene ERBA antibody
      • THA_HUMAN antibody
      • THRA antibody
      • Thra1 antibody
      • Thra2 antibody
      • Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (verba) oncogene homolog 1 formerly ERBA1) antibody
      • Thyroid hormone receptor alpha 1 antibody
      • Thyroid hormone receptor alpha 2 antibody
      • Thyroid hormone receptor alpha antibody
      • TR alpha 1 antibody
      • TR alpha 2 antibody
      • Tra1 antibody
      • Triiodothyronine receptor antibody
      • V-erbA-related protein 7 antibody
      see all

    Anti-Thyroid Hormone Receptor alpha 1+2 antibody images

    • ab15543 staining Thyroid Hormone Receptor alpha 1 in colon carcinoma at 1/100 dilution by Immunohistochemistry (formalin/paraffin).

    References for Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab15543)

    ab15543 has not yet been referenced specifically in any publications.

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