Overview

  • Product nameAnti-TIAL1 antibody
    See all TIAL1 primary antibodies
  • Description
    Rabbit polyclonal to TIAL1
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide: QQGFGVDQSP SAAWMGGFGA QPPQGQAPPP VIPPPNQAGY GMASYQTQ, corresponding to a sequence within C terminal amino acids 328-375 of Human TIAL1

Properties

Applications

Our Abpromise guarantee covers the use of ab26257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent dilution.
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
  • Sequence similaritiesContains 3 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasmic granule. The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aging associated gene 7 protein antibody
    • Nucleolysin TIAR antibody
    • T cluster binding protein antibody
    • TCBP antibody
    • TIA 1 related nucleolysin antibody
    • TIA-1-related protein antibody
    • TIA1 cytotoxic granule associated RNA binding protein like 1 antibody
    • TIA1 related protein antibody
    • TIAL1 antibody
    • TIAR antibody
    • TIAR_HUMAN antibody
    see all

Anti-TIAL1 antibody images

  • Anti-TIAL1 antibody (ab26257) at 1.25 µg/ml

    Predicted band size : 42 kDa

References for Anti-TIAL1 antibody (ab26257)

This product has been referenced in:
  • Schäffler K  et al. A stimulatory role for the La-related protein 4B in translation. RNA 16:1488-99 (2010). ICC/IF ; Human . Read more (PubMed: 20573744) »
  • Linder B  et al. Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. Hum Mol Genet 17:3236-46 (2008). Read more (PubMed: 18664458) »

See all 2 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (cos7)
Specification cos7
Fixative Formaldehyde
Permeabilization Yes - Triton
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Submitted Oct 12 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"