Anti-TICAM2 antibody (Alkaline Phosphatase) (ab26086)

Overview

  • Product name
    Anti-TICAM2 antibody (Alkaline Phosphatase)
    See all TICAM2 primary antibodies
  • Description
    Rabbit polyclonal to TICAM2 (Alkaline Phosphatase)
  • Conjugation
    Alkaline Phosphatase
  • Specificity
    ab26086 recognises TICAM 2 protein.
  • Tested applications
    Suitable for: ELISA, Dot blot, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide from the unique amino-terminal end of the protein, conjugated to KLH (peptide was post-synthetically modified to achieve highest antigenicty before used for coupling to KLH using heterobifunctional cross linker).

Properties

Applications

Our Abpromise guarantee covers the use of ab26086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
Dot blot 1/20000.
WB 1/500 - 1/750. Predicted molecular weight: 27 kDa.

Target

  • Function
    Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • Tissue specificity
    Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • Sequence similarities
    Contains 1 TIR domain.
  • Domain
    The TIR domain mediates the interaction with TRAF6.
  • Post-translational
    modifications
    Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • Cellular localization
    Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Putative NF-kappa-B-activating protein 502 antibody
    • TCAM2_HUMAN antibody
    • TICAM-2 antibody
    • TICAM2 antibody
    • TIR containing adapter molecule 2 antibody
    • TIR domain containing adaptor protein antibody
    • TIR domain-containing adapter molecule 2 antibody
    • TIRAP 3 antibody
    • TIRAP3 antibody
    • TIRAP3a short form antibody
    • TIRP antibody
    • Toll-like receptor adaptor protein 3 antibody
    • Toll/interleukin-1 receptor domain-containing protein antibody
    • TRAM antibody
    • TRIF-related adapter molecule antibody
    see all

References

ab26086 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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