Overview

  • Product name
    Tilmicosin
  • Description
    Macrolide antibiotic agent
  • Biological description
    Macrolide antibiotic agent. Inhibits protein synthesis. Shows more potent effects against Gram-positive bacteria than Gram-negative strains (MIC values are 7 and 58 μM for Streptococcus suis, Actinomyces pyogenes and Gram-negative strains respectively) in vivo. Orally active.
  • Purity
    > 99%

Properties

  • Chemical name
    (4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]ethyl]-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione
  • Molecular weight
    869.13
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C46H80N2O13
  • CAS Number
    108050-54-0
  • PubChem identifier
    5282521
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 5 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3C[C@@H](C[C@@H](C3)C)C)C)\C)CO[C@H]4[C@@H]([C@@H]([C@@H]([C@H](O4)C)O)OC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Abdel-Daim MM  et al. Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice. Can J Physiol Pharmacol 93:45-51 (2015). Read more (PubMed: 25429612) »
  • Chen X  et al. Preparation and evaluation of tilmicosin-loaded hydrogenated castor oil nanoparticle suspensions of different particle sizes. Int J Nanomedicine 9:2655-64 (2014). Read more (PubMed: 24920902) »
  • Jordan FT & Horrocks BK The minimum inhibitory concentration of tilmicosin and tylosin for mycoplasma gallisepticum and Mycoplasma synoviae and a comparison of their efficacy in the control of Mycoplasma gallisepticum infection in broiler chicks. Avian Dis 40:326-34 (0). Read more (PubMed: 8790882) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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