Overview

  • Product nameAnti-Timeless antibody
    See all Timeless primary antibodies
  • Description
    Rabbit polyclonal to Timeless
  • Specificityab51519 recognises the C terminal region of Timeless containing a SANT domain.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse Timeless aa 1178-1197 (C terminal).
    Sequence:

    SGTPRVHRKKRFQIEDEDD

Properties

Applications

Our Abpromise guarantee covers the use of ab51519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 139 kDa (predicted molecular weight: 139 kDa).
ELISA Use at an assay dependent dilution.

Target

  • FunctionRequired for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
  • Tissue specificityExpressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
  • Sequence similaritiesBelongs to the timeless family.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ12640 antibody
    • FLJ20714 antibody
    • hTIM antibody
    • Protein timeless homolog antibody
    • TIM antibody
    • TIM_HUMAN antibody
    • TIM1 antibody
    • Timeless antibody
    • timeless circadian clock 1 antibody
    • timeless circadian clock antibody
    • timeless homolog antibody
    • TIMELESS1 antibody
    • Tof1 homolog antibody
    see all

Anti-Timeless antibody images

  • Anti-Timeless antibody (ab51519) at 1/500 dilution

    Predicted band size : 139 kDa
    Observed band size : 139 kDa

References for Anti-Timeless antibody (ab51519)

ab51519 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"