Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceMDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRD
    • Molecular weight139 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab113078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Timeless antibody (ab50943)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: 100% dH2O

General Info

  • Alternative names
    • FLJ12640
    • FLJ20714
    • hTIM
    • Protein timeless homolog
    • TIM
    • TIM_HUMAN
    • TIM1
    • Timeless
    • timeless circadian clock
    • timeless circadian clock 1
    • timeless homolog
    • TIMELESS1
    • Tof1 homolog
    see all
  • FunctionRequired for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
  • Tissue specificityExpressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.
  • Sequence similaritiesBelongs to the timeless family.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Timeless peptide (ab113078)

ab113078 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"