Overview

  • Product name
    Anti-TIMM22 antibody [EPR9973]
  • Description
    Rabbit monoclonal [EPR9973] to TIMM22
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human TIMM22 (UniProt: Q9Y584)

  • Positive control
    • A673, T47D, A431 and BxPC-3 cell lysates
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab167423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 20 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Relevance
      TIMM22 is an essential core component of the TIM22 protein insertion complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated, signal-gated hydrophilic high-conductance channel. It forms a twin-pore translocase that uses the membrane potential as an external driving force in 2 voltage-dependent steps.
    • Cellular localization
      Mitochondrion inner membrane; Multi-pass membrane protein.
    • Database links
    • Alternative names
      • Mitochondrial import inner membrane translocase subunit Tim22 antibody
      • Putative membrane protein antibody
      • Testis expressed sequence 4 antibody
      • TEX 4 antibody
      • TEX4 antibody
      • TIM 22 antibody
      • TIM22 antibody
      • TIMM 22 antibody
      • Translocase of inner mitochondrial membrane 22 homolog antibody
      see all

    Images

    • All lanes : Anti-TIMM22 antibody [EPR9973] (ab167423) at 1/1000 dilution

      Lane 1 : A673 cell lysate
      Lane 2 : T47D cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : BxPC-3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : goat anti-rabbit HRP antibody at 1/2000 dilution

      Predicted band size: 20 kDa

    References

    This product has been referenced in:
    • Thompson K  et al. Recurrent De Novo Dominant Mutations in SLC25A4 Cause Severe Early-Onset Mitochondrial Disease and Loss of Mitochondrial DNA Copy Number. Am J Hum Genet 99:860-876 (2016). Read more (PubMed: 27693233) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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