Application notesIs unsuitable for Flow Cyt,ICC or IP.
FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Sequence similaritiesBelongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain.
Post-translational modificationsThe activity of TIMP1 is dependent on the presence of disulfide bonds.
ab109125, at 1/250 dilution staining TIMP1 in paraffin-embedded Human liver tissue, by Immunohistochemistry.
Western blot - TIMP1 antibody [EPR1550] (ab109125)
Anti-TIMP1 antibody [EPR1550] (ab109125) at 1/1000 dilution + TIMP1 recombinant protein at 10 µg
Predicted band size : 23 kDa
References for Anti-TIMP1 antibody [EPR1550] (ab109125)
This product has been referenced in:
Li T et al. Effects of small interfering RNA-mediated downregulation of the Krüppel-like factor 4 gene on collagen metabolism in human hepatic stellate cells. Mol Med Rep12:3972-8 (2015).
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