FunctionComplexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
Sequence similaritiesBelongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain.
Post-translational modificationsThe activity of TIMP1 is dependent on the presence of disulfide bonds.
References for Anti-TIMP1 antibody [RM0136-6A34] (ab86482)
This product has been referenced in:
Delfín DA et al. Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases. Neuromuscul Disord22:1006-14 (2012).
Read more (PubMed: 22749475) »
Duarte S et al. TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury. Hepatology56:1074-85 (2012).
Read more (PubMed: 22407827) »