Overview

  • Product name
  • Description
    Rabbit polyclonal to TIMP2
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide derived from the N terminal half of human TIMP2.

  • Positive control
    • Paraffin embedded Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab74216 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notes
    IHC-P: 1/50 for 10 min at RT.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 24 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
    • Sequence similarities
      Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • Post-translational
      modifications
      The activity of TIMP2 is dependent on the presence of disulfide bonds.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • CSC 21K antibody
      • CSC-21K antibody
      • CSC21K antibody
      • Metalloproteinase inhibitor 2 antibody
      • Metalloproteinase inhibitor 2 precursor antibody
      • TIMP 2 antibody
      • TIMP metallopeptidase inhibitor 2 antibody
      • TIMP-2 antibody
      • TIMP2 antibody
      • TIMP2_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 2 antibody
      • Tissue inhibitor of metalloproteinases 2 antibody
      see all

    Images

    • ab74216 at 1/50 dilution staining TIMP2 in human colon carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

    References

    ab74216 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab74216.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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