Anti-TIMP3 antibody, prediluted (ab15561)

Overview

  • Product name
    Anti-TIMP3 antibody, prediluted
    See all TIMP3 primary antibodies
  • Description
    Rabbit polyclonal to TIMP3, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Rabbit, Human, Baboon
    Does not react with: Rat, Cow, Pig, Bird
  • Immunogen

    Synthetic peptide (Human) (C terminal).

  • Positive control
    • Placenta or Breast carcinoma

Applications

Our Abpromise guarantee covers the use of ab15561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Working dilution: ready-to-use for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
    • Involvement in disease
      Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
    • Sequence similarities
      Belongs to the protease inhibitor I35 (TIMP) family.
      Contains 1 NTR domain.
    • Cellular localization
      Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • HSMRK222 antibody
      • K222 antibody
      • K222TA2 antibody
      • Metalloproteinase inhibitor 3 antibody
      • MIG 5 protein antibody
      • MIG5 protein antibody
      • Protein MIG 5 antibody
      • Protein MIG-5 antibody
      • SFD antibody
      • Sorsby fundus dystrophy pseudoinflammatory antibody
      • TIMP 3 antibody
      • TIMP metallopeptidase inhibitor 3 antibody
      • TIMP-3 antibody
      • TIMP3 antibody
      • TIMP3_HUMAN antibody
      • Tissue Inhibitor of Metalloproteinase 3 antibody
      • Tissue inhibitor of metalloproteinases 3 antibody
      • Tissue inhibitor of metalloproteinases3 antibody
      see all

    Images

    • Ab15561 positively staining formalin fixed paraffin embedded human placenta tissue.

       

    References

    ab15561 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for your enquiry. Please let me apologise for or mistake. ab15560, ab15561 and ab15562 are all 0.2mgml-1 pre-diluted sera ready for IHC. I have updated our datasheets accordingly. Please do not hesitate to contact me should you requir...

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