Overview

  • Product nameAnti-Tin2 antibody
    See all Tin2 primary antibodies
  • Description
    Rabbit polyclonal to Tin2
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 396-445 (SDEEENGQGE GKESLENYQK TKFDTLIPTL CEYLPPSGHG AIPVSSCDCR) of Human Tin2 (NP_001092744).

  • Positive control
    • MCF7 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab82998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/1562500.

WB Use a concentration of 1 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionComponent of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.
  • Tissue specificityDetected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Involvement in diseaseDefects in TINF2 are a cause of dyskeratosis congenita autosomal dominant (ADDKC) [MIM:127550]; also known as dyskeratosis congenita Scoggins type. ADDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
    Defects in TINF2 are a cause of retinopathy exudative with bone marrow failure (ERBMF) [MIM:268130]; also known as Revesz syndrome. ERBMF is characterized by bilateral exudative retinopathy, bone marrow hypoplasia, nail dystrophy, fine hair, cerebellar hypoplasia, and growth retardation.
  • DomainThe TBM domain mediates interaction with TERF1.
  • Cellular localizationNucleus. Chromosome > telomere. Associated with telomeres.
  • Information by UniProt
  • Database links
  • Alternative names
    • AW552114 antibody
    • D14Wsu146e antibody
    • DKCA3 antibody
    • MGC94711 antibody
    • TERF 1 (TRF 1) interacting nuclear factor 2 antibody
    • TERF 1 interacting nuclear factor 2 antibody
    • TERF1 (TRF1) interacting nuclear factor 2 antibody
    • TERF1 interacting nuclear factor 2 antibody
    • TERF1-interacting nuclear factor 2 antibody
    • Tin 2 antibody
    • TIN2 antibody
    • TINF 2 antibody
    • Tinf2 antibody
    • TINF2_HUMAN antibody
    • TRF 1 interacting nuclear factor 2 antibody
    • TRF1 interacting nuclear factor 2 antibody
    • TRF1-interacting nuclear protein 2 antibody
    see all

Anti-Tin2 antibody images

  • Anti-Tin2 antibody (ab82998) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 50 kDa
    Observed band size : 50 kDa
    Additional bands at : 90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Tin2 antibody (ab82998)

ab82998 has not yet been referenced specifically in any publications.

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