Overview

  • Product nameAnti-TINAG antibody
    See all TINAG primary antibodies
  • Description
    Rabbit polyclonal to TINAG
  • Specificityab105512 only recognises TINAG isoform 1 (TIN1), not isoform 2 (TIN2)
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 251-300 (VAADRIAIQS KGRYTANLSP QNLISCCAKN RHGCNSGSID RAWWYLRKRG) of Human TINAG (NP_055279).

  • Positive control
    • PANC1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 55 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
  • Tissue specificityExpressed in the kidney cortex, small intestine and cornea.
  • Sequence similaritiesBelongs to the peptidase C1 family.
    Contains 1 SMB (somatomedin-B) domain.
  • Developmental stageInitially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.
  • Post-translational
    modifications
    It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • TIN AG antibody
    • TIN-Ag antibody
    • TIN1 antibody
    • TIN2 antibody
    • TINAG antibody
    • TINAG_HUMAN antibody
    • Tubulointerstitial nephritis antigen antibody
    see all

Anti-TINAG antibody images

  • Anti-TINAG antibody (ab105512) at 1 µg/ml + PANC1 cell lysate at 10 µg

    Predicted band size : 55 kDa

References for Anti-TINAG antibody (ab105512)

ab105512 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"